Programme

STA1 What’s new in pre-eclampsia? Mark Brown St. George Hospital & University of NSW, Department of Renal Medicine, Sydney, Australia STA2 Placentation and pre-eclampsia - inflammatory and immunological issues Christopher Redman University of Oxford, Nuffield Department of Obstetrics and Gynaecology, Oxford, UK STA3 Novel therapies for preeclamsia Ananth Karumanchi Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA PL136 Renal disease before, during and after preeclampsia Markus G. Mohaupt University Hospital Bern, Department of Nephrology, Hypertension and Clinical Pharmacology, Bern, Switzerland

O4 Genome wide sequencing approaches to identify missing heritability of preeeclampsia Eric Mosessu¹, Phillip Meltonsu¹, Matthew Johnsonsu², Dnyanada Gokhale-Agashesu¹, Alex Reasu¹, Richard Allcocksu³, John Blangerosu², Shaun Brenneckesu^{4 1}University of Western Australia, Centre for Genetic Origins of Health and Disease, Perth, Australia
²University of Texas Health Science Center at San Antonio, South Texas Diabetes and Obesity Institute, Brownsville, USA
³University of Western Australia, School Pathology and Laboratory Medicine, Perth, Australia
⁴Royal Women's Hospital / University of Melbourne, Pregnancy Research Centre, Department of Perinatal Medicine, Melbourne, Australia O5 Next-generation sequencing studies in Finnish preeclampsia cohorts Tea Kaartokallio¹, JIngwen Wang², Hong Jiao², Seppo Heinonen³, Eero Kajantie⁴, Juha Kere², Katja Kivinen⁵, Anneli Pouta⁶, Hannele Laivuori^{1 1}University of Helsinki and Helsinki University Hospital, Medical and Clinical Genetics, Helsinki, Finland
²Karolinska Institute, Department of Biosciences and Nutrition, Center for Innovative Medicine and Science for Life Laboratory, Stockholm, Sweden
³University of Helsinki and Helsinki University Hospital, Obstetrics and Gynecology, Helsinki, Finland
⁴National Institute for Health and Welfare, Department of Chronic Disease Prevention, Diabetes Prevention Unit, Helsinki, Finland
⁵University of Cambridge, Division of Cardiovascular Medicine, Cambridge, UK
⁶National Institute for Health and Welfare, Department of Children, Young People and Families, Oulu, Finland O6 Association between fetal congenital heart defects and maternal risk of hypertensive disorders of pregnancy in concurrent and subsequent pregnancies Heather Boyd¹, Saima Basit¹, Ida Behrens¹, Elisabeth Leirgul², Henning Bundgaard³, Jan Wohlfahrt¹, Mads Melbye¹, Nina Øyen^{2 1}Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark
²University of Bergen, Department of Global Public Health and Primary Care, Bergen, Norway
³Copenhagen University Hospital (Rigshospitalet), Heart Centre, Copenhagen, Denmark O7 Epigenome of the circadian clock pathway of placental and newborn tissues in pre-eclampsia Caroline Van den Berg¹, Ines Chaves², Emilie Herzog¹, Sten Willemsen³, Bert Van der Horst², Régine Steegers-Theunissen^{1 1}Erasmus MC, Department of Obstetrics & Gynecology, Rotterdam, The Netherlands
²Erasmus MC, Department of Genetics, Rotterdam, The Netherlands
³Erasmus MC, Department of Biostatistics, Rotterdam, The Netherlands
O8 Cardiovascular risk factors, renin-angiotensin system gene polymorphisms, pregnancy course and outcomes in women with different forms of hypertension Vasiliy Chulkov¹, Natalya Vereina¹, Sergei Sinitsin¹, Valentina Dolgushina^{2 1}South Ural State Medical University, Russia, Faculty Therapy Department, Chelyabinsk, Russia
²South Ural State Medical University, Russia, Department of Obstetrics and Gynecology, Chelyabinsk, Russia O9 The functional role of natriuretic peptides in preeclampsia Gábor Szabó, Bálint Nagy, János Rigó Jr. Semmelweis University, 1st Department of Obstetrics and Gynaecology, Budapest, Hungary

O11 Evaluation of the endocannabinoid system in preeclampsia Attila Molvarec¹, Gergely Fügedi¹, Miklós Molnár², Eszter Szabó³, Júlia Schönléber¹, János Rigó Jr^{1 1}Semmelweis University, 1st Department of Obstetrics and Gynaecology, Budapest, Hungary
²Semmelweis University, Institute of Pathophysiology, Budapest, Hungary
³Semmelweis University, 1st Department of Pediatrics, Budapest, Hungary O12 Analysis of the molecular and cellular mechanisms regulated by magnesium sulphate in an in vitro model of the human placenta Rachel Williamson¹, Gerard O'Keeffe², Louise Kenny^{1 1}University College Cork, 1st Department of Obstetrics and Gynaecology, Cork, Ireland
²University College Cork, Department of Anatomy and Neuroscience, Cork, Ireland O13 Catechol-O-methyltransferase deficiency leads to hypersensitivity on the pressor response against angiotensin II Norikazu Ueki¹, Satoru Takeda¹, Megumi Kanasaki², Daisuke Koya², Keizo Kanasaki^{2 1}Juntendo University Faculty of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan
²Kanazawa Medical University, Department of Diabetology and Endocrinology, Ishikawa, Japan O14 Is preeclampsia a variant of Liddles syndrome with enhanced activity of the epithelial sodium channel in the kidneys? Lise Hald Nielsen1, Per Ovesen¹, Boye Jensen^{2 1}Aarhus University, Department of Gynecology and Obstetrics, Aarhus, Denmark
²Odense University Hospital, Department of Cardiovascular and Renal Research, Odense, Denmark O15 Adipose tissue and adipocytokine in preeclampsia: New insights into danger signals and inflammation Katsuhiko Naruse Nara Medical University, Department of Obstetrics & Gynecology, Kashihara, Japan O10 Increased Maternal and Fetal HDL Cholesterol Efflux Capacity and Placental CYP27A1 Expression in Pre-eclampsia Hiten Mistry¹, Lesia Kurlak², Yosef Mansour³, Line Zurkinden¹, Markus Mohaupt⁴, Geneviève Escher^{1 1}University of Bern, Department of Nephrology, Hypertension and Clinical Pharmacology, Berne, Switzerland
²University of Nottingham, Obstetrics and Gynecology, Nottingham, UK
³King's College London, Women's Health Academic Centre, London, UK
⁴University of Bern, Department of Nephrology, Hypertension and Clinical Pharmacology, Berne, UK

O16 Marinobufagenin as a promising preeclampsia risk assessment marker: purification from toad venom and LC-MS identification in human plasma Charline Lenaerts¹, Liz Bond², Robin Tuytten², Bertrand Blankert^{1 1}University of Mons, Laboratory of Pharmaceutical Analysis, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, Mons, Belgium
²Metabolomic Diagnostics, Cork, Ireland O18 Oxidative stress in preeclampsia Hajnalka Hejja¹, Nora Fekete², Balint Alasztics¹, Jozsef Gabor Joo¹, Attila Molvarec ¹, Katalin Szabo-Taylor², Edit Buzas², Janos Rigo¹, Eva Pallinger^{2 1}Semmelweis University, 1st Department of Obstetrics and Gynaecology, Budapest, Hungary
²Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary O19 Decreased plasma hemopexin activity in preeclampsia is associated with decreased plasma AT-1 receptor leves and increased placental and monocyte AT-1 receptor expression Floor Spaan¹, Theo Borghuis¹, Paul De Vos¹, Harry Van Goor¹, Maria Van Pampus², Marijke Faas^{1 1}University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands
²University Medical Center Groningen, Department of Obstetrics & Gynecology, Groningen, The Netherlands O20 NT-pro-BNP levels as a marker of high clinical risk in pregnancy Marcela Cleila Cabo Fustaret, Ana Escobar, Fedor Novo, Ricardo Illia, Carlos Rivas, Matias Uranga Imaz, Guillermo Lobenstein, Roberto Mayer, Patricia Olejnik, Tomas Garcia Balcarce, Guido Manrique Hospital Alemán, Department of Cardiology /Obstetric and Gynecology , Buenos Aires, Argentina O21 First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with later pre-eclampsia Elina Keikkala¹, Sini Koskinen¹, Piia Vuorela^1,2, Hannele Laivuori^1,3,4, Jarkko Romppanen⁵, Seppo Heinonen¹, Ulf-Håkan Stenman^{6 1}Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
²Obstetrics and Gynecology, Porvoo Hospital, Porvoo, Finland
³Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁴Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland
⁵Eastern Finland Laboratory Centre, Kuopio, Finland
⁶Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

O22 Correlation of sFlt-1/PlGF ratio with time to delivery or preterm birth in PROGNOSIS (Prediction of short-term outcome in pregnant women with suspected preeclampsia study) Harald Zeisler¹, Elisa Llurba², Frederic Chantraine³, Manu Vatish⁴, Anne Cathrine Staff⁵, Maria Sennström⁶, Matts Olovsson⁷, Shaun P. Brennecke⁸, Holger Stepan⁹, Deirdre Allegranza¹⁰, Carina Dinkel¹¹, Maria Schoedl¹¹, Martin Hund¹⁰, Stefan Verlohren^{12 1}Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
²Department of Obstetrics, Maternal-Fetal Medicine Unit, Hospital Universitari Vall d´Hebron, Barcelona, AND Maternal and Child Health and Development Network (SAMID) RD12/0026, Instituto de Salud Carlos III, Spain
³Department of Obstetrics and Gynecology, University of Liege, CHR de la Citadelle, Liege, Belgium
⁴Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK (previously University Hospitals NHS Trust, Coventry, UK)
⁵Department of Gynecology and Department of Obstetrics, Oslo University Hospital and University of Oslo, Oslo, Norway
⁶Department of Women’s and Children’s Health, Karolinska University Hospital, AND Karolinska Institute, Stockholm, Sweden
⁷Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
⁸Pregnancy Research Centre, Department of Perinatal Medicine, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia
⁹Department of Obstetrics, University of Leipzig, Leipzig
¹⁰Roche Diagnostics International Ltd, Rotkreuz, Switzerland
¹¹Roche Diagnostics GmbH, Penzberg, Germany
¹²Department of Obstetrics, Campus Virchow-Klinikum Charité, Berlin, Germany O23 STEPS (Study of Early Preeclampsia in Spain): sFlt-1/PlGF for the prediction of early-onset preeclampsia in singleton pregnancies Alfredo Perales¹, Juan Luis Delgado², María de la Calle³, José A García-Hernández⁴, Ana Isabel Escudero⁵, José Manuel Campillos⁶, María Desamparados Sarabia², Begoña Laíz¹, Marta Duque³, Mercedes Navarro⁴, Pilar Calmarza⁶, Martin Hund⁷, Francisco V Álvarez^{5 1}Hospital Universitario La Fe, Valencia, Sp^ain
²Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
³Hospital Universitario La Paz, Madrid, Spain
⁴Hospital Universitario Materno-Infantil, Gran Canaria, Spain
⁵Hospital Universitario Central de Asturias, Oviedo, Spain
⁶Hospital Universitario Miguel Servet, Zaragoza, Spain
⁷Roche Diagnostics International Ltd, Rotkreuz, Switzerland O24 Prediction of pre-eclampsia in obese nulliparous women Matias Vieira¹, Dharmintra Pasupathy¹, Robyn North¹, Lesley McCowen², Louise Kenny³, Lucilla Poston^{1 1}King's College London, Division of Women's Health, London, UK
²University of Auckland, Department of Obstetrics and Gynecology, Auckland, New Zealand
³University College Cork, Department of Obstetrics and Gynecology, Cork, Ireland O25 Evaluation of the value of the first and third trimester maternal mean platelet volume (MPV) for prediction of pre-eclampsia Maryam Kashanian Iran University of Medical Sciences, 3rd Department of Obstetrics, Tehran, Iran O27 Predicting Preeclampsia in a second pregnancy Doris Campbell, Sohinee Bhattacharya University of Aberdeen, Department of Obstetrics & Gynecology, Aberdeen, UK

O28 Effect of folic acid supplementation in pregnancy on preeclampsia – Folic Acid Clinical Trial (FACT) Shi Wu Wen, Ruth Rennicks-White, Josee Champagne, Natalie Rybak, Laura Gaudet, Mark Walker The Ottawa Hospital, Department of Obstetrics, Gynecology and Newborn Care, Ottawa, Canada O29 The impact of low dose aspirin after positive first trimester screening for pre-eclampsia Ioana-Claudia Lakovschek¹, Bence Csapo¹, Vassiliki Kolovetsiou-Kreiner¹, Christina Stern¹, Karoline Mayer-Pickel¹, Uwe Lang¹, Barbara Obermayer-Pietsch², Mila Cervar-Zivkovic^{1 1}Medical University of Graz, Department of Obstetrics & Gynecology, Graz, Austria
²Medical University of Graz, Department of Internal Medicine, Graz, Austria O30 Diet and Preeclampsia: A prospective multicentre unmatched Case Control Study in Ethiopia Mulualem Endeshaw Rift Valley University, 3rd Department of Obstetrics, Ethiopia (Bahir Dar), Ethiopia O31 Magnesium homeostasis and gestational hypertension Ragnar Rylander BioFAct Environmental Health Research Centre, Public Health, Lerum, Sweden O32 Pre-eclampsia and thrombophilia: prevention issues Ekaterina Zhuravleva, Viktoriya Bitsadze, Akexander Makatsariya First IM Sechenov Moscow State Medical University, Obstetrics and Gynecology, Moscow, Russia

P34 Role of high-mobility group A1 protein in trophoblast invasion Yuka Uchikura¹, Keiichi Matsubara¹, Yuko Matsubara¹, Miki Mori^{2 1}Ehime University, Department of Obstetrics and Gynecology, Toon, Japan
²Ehime Prefectural Central Hospital, Department of Obstetrics and Gynecology, Matsuyama, Japan P35 Novel interaction of placental caveolin-1 expression with markers of oxidative stress and the renin-angiotensin system (RAS) in pre-eclampsia Hiten Mistry¹, Anna Czajka², Marta Hentschke³, Carlos Poli-de-Figueiredo³, Bartira Pinheiro da Costa³, Fiona Broughton Pipkin⁴, Lesia Kurlak^{4 1}University of Bern, Department of Nephrology, Hypertension and Clinical Pharmacology, Berne, Switzerland ²King's College London, Diabetes Research Group, London, UK
³PUCRS, Laboratory of Nephrology , Porto Alegre, Brazil
⁴University of Nottingham, Department of Obstetrics & Gynecology, Nottingham, UK P36 Identifying a novel link between preeclampsia and chronic hypertension in the MTHFR-gene using the population based Norwegian HUNT Study Liv Cecilie Thomsen¹, Nina McCarthy², Phillip Melton², Gemma Cadby², Rigmor Austgulen³, Eric Moses², Line Bjørge⁴, Ann-Charlotte Iversen^{3 1}Norwegian University of science and Technology (NTNU), Centre of Molecular Inflammation Research , Bergen, Norway
²University of Western Australia, Centre for Genetic Origins of Health and Disease, Perth, Australia
³Norwegian University of Science and Technology (NTNU), Centre of Molecular Inflammation Research, Trondheim, Norway
⁴Haukeland University Hospital, Department of Obstetrics & Gynecology, Bergen, Norway P37 Alterations in maternal and fetal plasma soluable endothelial leukocyte adhesion molecule-1 (sE-selectin) concentrations in women with pre-eclampsia Lesia Kurlak¹, Heidi Jamin², Markus Mohaupt², Hiten Mistry^{2 1}University of Nottingham, Obstetrics and Gynecology, Nottingham, UK
²University of Bern, Department of Nephrology, Hypertension and Clinical Pharmacology, Berne, Switzerland P38 Strong inhibitory effect of preeclampsia serum on angiogenesis using in vitro angiogenesis test Uotila Uotila¹, Anita Virtanen¹, Tarja Toimela², Riina Sarkanen², Outi Huttala², Tuula Heinonen^{2 1}Tampere University Hospital, Department of Obstetrics and Gynecology, Tampere, Finland
²FICAM, School of Medicine, Tampere, FICAM, Tampere, Finland P39 Connection between placenta specific miRNA clusters and preeclampsia: a hypothetical miRNA-mRNA interaction network Orsolya Biró, Bálint Nagy, János Rigó Jr. Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary P40 MIR-21 A and MIR-221 overexpression in placental tissue of preeclamptic patients Iveta Svecova¹, Martin Vazan², Pavol Zubor¹, Jan Danko¹, Zora Lasabova^{2 1}Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Department of Obstetrics & Gynecology, Martin, Slovakia
²Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Institut of Molecular Biology, Martin, Slovakia P41 The role of IL-10 polymorphism in pathology of hypertensive disorders in pregnancy Pavol Zubor¹, Zora Lasabova², Eva Jezkova¹, Andrea Mendelova¹, Iveta Svecova¹, Jan Danko^{1 1}Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Department of Obstetrics & Gynecology, Martin, Slovakia
²Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Institut of Molecular Biology, Martin, Slovakia P42 TNF-ALPHA gene polymorphism in pathology of preeclampsia Pavol Zubor¹, Andrea Mendelova², Imrich Zigo¹, Maria Skerenova³, Eva Jezkova², Jan Danko^{1 1}Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Department of Obstetrics & Gynecology, Martin, Slovakia
²Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Institut of Molecular Biology, Martin, Slovakia
³Jessenius Medical Faculty, Comenius University, Martin, Slovakia, Department of Medical Biochemistry, Martin, Slovakia P43 Characterization of monocyte phenotype and polarization in preeclampsia and intrauterine fetal growth restriction Thushari Alahakoon¹, Heather Medbury², Helen Williams², Nicole Fewings², Xin Wang², Vincent Lee^{3 1}Westmead Hospital, Australia, Department of Obstetrics and Gynecology, Sydney, Australia
²University of Sydney, Sydney Medical School, Sydney, Australia
³Westmead Hospital, Australia, Department of Renal Medicine, Sydney, Australia P44 Syncytiotrophoblast extracellular membrane vesicles from preeclamptic placentae show reduced abilities to guide monocyte maturation and activation as well as reduced activation of cytotoxicity of regulatory T-cells and NK-cells Claudia Göhner¹, Jolien Fledderus², Justine Fitzgerald³, Ekkehard Schleußner³, Udo Markert³, Torsten Plösch¹, Sicco Scherjon¹, Marijke Faas^{2 1}University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, The Netherlands
²University Medical Center Groningen, Department of Pathology and Medical Biology, Division of Medical Biology, Immunoendocrinology, Groningen, The Netherlands
³University Hospital Jena, Department of Obstetrics, Placenta-Lab, Jena, Germany P45 Target cells of pregnancy-associated extracellular vesicles Árpád Ferenc Kovács¹, Nóra Fekete¹, Bálint Alasztics², Gábor Joó², Mária Prosszer², Edit Buzás¹, János Rigó Jr.², Éva Pállinger^{1 1}Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
²Semmelweis University, 1st Department of Obstetrics and Gynaecology, Budapest, Hungary P46 Dysregulated level of novel circulating autoantibodies in preeclampsia Kjartan Moe¹, Harald Heidecke², Ralf Dechend³, Anne Cathrine Staff^{1 1}University of Oslo, Institute for Clinical Medicine, Oslo, Norway
²Celltrend GmbH, Luckenwalde, Germany
³The Charitè, Franz-Vollhard Clinic, HELIOS Clinic, Berlin, Germany P47 First trimester urine and serum metabolomics to predict preeclampsia and gestational hypertension Marie Austdal¹, Line Tangerås², Ragnhild Skråstad³, Kjell Salvesen⁴, Rigmor Austgulen⁵, Tone Bathen⁶, Ann-Charlotte Iversen^{7 1}Norwegian University of Science and Technology and St. Olavs Hospital, Department of Circulation and Medical Imaging, Trondheim, Norway
²Norwegian University of Science and Technology and St. Olavs Hospital, Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine, Trondheim, Norway
³Norwegian University of Science and Technology and St. Olavs Hospital, Department of Laboratory Medicine, Children's and Women's Health, Trondheim, Norway
⁴St. Olavs Hospital, National Centre for Fetal Medicine, Trondheim, Norway
⁵Norwegian University of science and Technology (NTNU), Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine, Trondheim, Norway
⁶Norwegian University of Science and Technology, Department of Circulation and Medical Imaging, Trondheim, Norway
⁷Norwegian University of Science and Technology, Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine, Trondheim, Norway P48 Possible laboratory markers and anthropometric women with preeclampsia - preliminary results Natine Fuzihara Rosa, Stephany Risnic Chvaicer, Ana Paula de Almeida Righi, Claudia Valéria Chagas Siqueira, Diego Gomes Ferreira, Maria Renata Lopes Natale Poltronieri, Rogerio Gomes dos Reis Guidoni, Sergio Floriano Toledo, Leda Ferraz, Patricia Lopes Andrade, Francisco Lazaro Pereira Sousa, Vivian Macedo Gomes Marçal
UNILUS - Lusiada Foundation, 1st Department of Obstetrics and Gynaecology, Santos, Brazil P50 Microalbuminuria is a predictor of adverse pregnancy outcomes including preeclampsia Mathini Jayaballa¹, Shreya Sood², Thushari Alahakoon³, Suja Padmanabhan⁴, Wah Cheung⁴, Vincent Lee^{1 1}Westmead Hospital, Australia, Department of Renal Medicine, Sydney, Australia
²University of Sydney, Sydney Medical School, Sydney, Australia
³Westmead Hospital, Australia, Department of Obstetrics & Gynecology, Sydney, Australia
⁴Westmead Hospital, Australia, Department of Endocrinology, Sydney, Australia P51 Screening for preeclampsia in the first trimester: a reduced fat mass increases the risk in normo BMI patients Grazia Maria Tiralongo¹, Ilaria Pisani¹, Giulia Gagliardi¹, Damiano Lo Presti¹, Roberta Licia Scala², Barbara Vasapollo³, Gianpaolo Novelli⁴, Angela Andreoli⁵, Herbert Valensise^{1 1}University of Tor Vergata, Department of Obstetrics and Gynecology, Rome, Italy
²San Giovanni Calibita Fatebenefratelli Hospital, Department of Obstetrics and Gynecology, Rome, Italy
³San Giovanni Calibita Fatebenefratelli Hospital, Fatebenefratelli Association for Research, Rome, Italy
⁴San Sebastiano Martire Hospital, Department of Cardiology, Frascati (Rome), Italy
⁵University of Tor Vergata, Department of Physiology, Rome, Italy P52 Prevalence of preeclampsia in patients of pre-gestational diabetic pregnancy in Bangladesh Mobashera Jahan¹, Md Hasanuzzaman¹, Sharmin Mahbuba¹, K. Leena², Gias U. Ahsan¹, Thomas J. Kuehl³, M. Uddin^{3 1}North South University, Department of Public Health, Dhaka, Bangladesh
²Brac University, James P. Grant School of Public Health, Dhaka, Bangladesh
³Baylor College of Medicine, Houston, Texas, USA, Obstetrics and Gynecology, Houston, USA P53 Body mass index before pregnancy and hypertensive disorders in following pregnancy Ana Jakovljevic¹, Mirjana Bogavac², Aleksandra Nikolic³, Mirjana Milosevic-Tosic³, Zagorka Lozanov-Crvenkovic^{4 1}University of Novi Sad Medical Faculty, Clinical Centre of Vojvodina , Centre for Laboratory Medicine, Novi Sad, Serbia
²University of Novi Sad Medical Faculty, Clinical Centre of Vojvodina, Department of Obstetrics and Gynecology, Novi Sad, Serbia
³University of Novi Sad Medical Faculty, Clinical Centre of Vojvodina, Emergency Center, Urgent Laboratory at Department of Obstetrics and Gynecology, Novi Sad, Serbia
⁴University of Novi Sad Faculty, Faculty of Science Department of Mathematics and Informatics, Novi Sad, Serbia

STA54 Preeclampsia – Myths are still stronger than scientific data Berthold Huppertz Medical University of Graz, Institute of Cell Biology, Histology & Embryology, Graz, Austria STA55 Pathophysiology of preeclampsia from the view point of immunology Shigeru Saito¹, Arihiro Shiozaki¹, Akitoshi Nakashima¹, Yasushi Nakabayashi¹, Attila Molvarec², János Rigó Jr.^{2 1}University of Toyama, Obstetrics and Gynecology, Toyama, Japan
²Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary PL56 Lon-term consequences of preeclampsia Annetine Staff University of Oslo,Oslo, Norway PL138 Should we be using predictive tests for Pre-eclampsia in routine clinical practice? Louise Kenny University of Oslo, Norway

PL57 Angiogenic factors: from scientific data to clinical implementation Holger Stepan Leipzig University, Department of Obstetrics, Leipzig, Germany PL58 Low molecular weight heparin for prevention of severe preeclampsia and other placental mediated complications Michael Kupferminc Tel Aviv Medical Center, Tel Aviv University, Obstetrics and Gynecology, Tel Aviv, Israel PL59 The impact of classification of hypertensive disorders of pregnancy based on the ACOG 2013 and ISSHP 2014 criteria János Rigó Jr., Bálint Alasztics, Anikó Árokszállási, Noémi Dobó, Mária Prosszer, János Gábor Joó, Attila Molvarec Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary A new Database for all Preeclampsia Researchers. From the Global Pregnancy Collaboration Chritopher Redman University of Oxford, Nuffield Department of Obstetrics and Gynecology, Oxford, UK

O60 Treatment of hypertension in pregnancy Csaba Farsang St. Imre University Teaching Hospital, Budapest, Hungary O61 The Treatment of Antenatal Hypertension With Labetalol: A Prediction Model for Successful Response Daniel Stott, Mareike Bolten , Dana Paraschiv, Mona Salman , Katherine Clark, Nikos Kametas King's College London, Department of Women’s and Children’s Health, London, UK O62 Use of diuretics in the management of late-onset preeclampsia Péter Tamás^1,2, Eszter Hantosi^1,2, Bálint Farkas², József Bódis^{1,2 1}Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs
²Doctorial School of Health Sciences, Faculty of Health Sciences, University of Pécs, Hungary O63 Removal of Soluble Fms-like Tyrosine Kinase (sFlt-1) by Plasma-Specific Apheresis: Pilot Study in Women with Very Preterm Preeclampsia Wiebke Schaarschmidt Leipzig University, Obstetrics and Gynecology, Leipzig, Germany O64 Timing of delivery in Preeclampsia Helena Strevens Lund University, Department of Obstetrics and Gynecology, Lund, Sweden O65 Is there evidence to inform antihypertensive prescribing in pregnancy complicated by chronic hypertension: a systematic review Louise Webster, Frances Conti-Ramsden, Paul Seed, Catherine Nelson-Piercy, Lucy Chappell King's College London, Women's Health Academic Centre, London, UK

O66 Comparison of immediate delivery versus expectant management in women with severe early onset preeclampsia before 26 weeks of gestation Miriam F. Van Oostwaard¹, Leonoor Van Eerden², Monique W. De Laat³, Hans J. Duvekot⁴, Jan Jaap H.M. Erwich⁵, Kitty W.M. Bloemenkamp⁶, Antoinette Bolte⁷, Joost P.F. Bosma⁸, Steven V. Koenen⁹, René F. Kornelisse¹⁰, Bente Rethans³, Pieter Van Runnard Heimel¹¹, Hubertina C.J. Scheepers¹², Wessel Ganzevoort³, Ben Willem J. Mol¹³, Christianne J. De Groot¹⁴, Ingrid P.M. Gaugler-Senden^{15 1}Department of Obstetrics and Gynaecology, Beatrixziekenhuis, Gorinchem, The Netherlands
²Department of Obstetrics and Gynaecology, Maasstad Ziekenhuis, Rotterdam, The Netherlands
³Department of Obstetrics and Gynaecology, Academisch Medisch Centrum, Amsterdam, The Netherlands
⁴Department of Obstetrics and Gynaecology, Erasmus Medisch Centrum, Rotterdam, The Netherlands
⁵Department of Obstetrics and Gynaecology, Universitair Medisch Centrum Groningen, The Netherlands
⁶Department of Obstetrics and Gynaecology, Leids Universitair Medisch Centrum, Leiden, The Netherlands
⁷Department of Obstetrics and Gynaecology, Radboud Universitair Medisch Centrum, The Netherlands
⁸Department of Obstetrics and Gynaecology, Isala Ziekenhuis, Zwolle
⁹Department of Obstetrics and Gynaecology, Universitair Medisch Centrum Utrecht, The Netherlands
¹⁰Department of Paediatrics, Erasmus Medisch Centrum, Rotterdam, the Netherlands
¹¹Department of Obstetrics and Gynaecology, Maxima Medisch Centrum, Veldhoven, The Netherlands
¹²Department of Obstetrics and Gynaecology, Maastricht Universitair Medisch Centrum, The Netherlands
¹³School of Paediatrics and Reproductive Health, University of Adelaide, 5000 SA Australia
¹⁴Department of Obstetrics and Gynaecology, VU Universitair Medisch Centrum, Amsterdam, The Netherlands
¹⁵Department of Obstetrics and Gynaecology, Jeroen Bosch Ziekenhuis, ‘s-Hertogenbosch, The Netherlands O67 The cranial imaging in severe preeclampsia XiaoDan Di¹, Hui Mai², JinYing Yang¹, HuiShu Liu^{1 1}Guangzhou Women and Children’s Medical Center, Department of Obstetrics, GuangZhou, China ²The third affiliated hospital of Guangzhou Medical University, Department of Radiology, GuangZhou, China O68 Management of eclampsia and stroke during pregnancy Yasumasa Ono OHNO Ladies Clinic, Obstetrics and Gynecology, Iwakura, Japan O69 Visual Evoked Potential as neurophysiological evaluation of patients with severe PE and visual disturbances Ingrid Brussé Erasmus MC, Department of Obstetrics & Gynecology, Rotterdam, The Netherlands O70 What is the optimal management for screening, diagnosis and management of preeclampsia today? Mila Cervar-Zivkovics Medical University of Graz, Department of Gynecology and Obstetrics, Graz, Austria

O72 Monocyte-macrophage system in pregnancy complications from the prospective of extracellular vesicles Éva Pállinger¹, Nóra Fekete¹, Anikó Árokszállási², Gábor Joó², Edit Buzás¹, János Rigó Jr.^{2 1}Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
²Semmelweis University, 1st Department of Obstetrics and Gynaecology, Budapest, Hungary O73 The role of Th17/Treg imbalance in normal pregnancy and pre-eclampsia Dorota Darmochwal-Kolarz¹, Bogdan Kolarz², Magdalena Kludka-Sternik³, Jan Oleszczuk^{1 1}Medical University of Lublin, Department of Obstetrics and Perinatology, Lublin, Poland
²University of Rzeszow, Centre for Innovative Research in Medical and Natural Sciences, Rzeszow, Poland
³Medical University of Lublin, 3rd Department of Gynecology, Lublin, Poland O74 Granulocyte and monocyte phagocytosis index affected by plasma factors in normal and preeclamptic pregnancy Rudolf Lampé, Ágnes Kövér, Robert Póka University of Debrecen, Department of Obstetrics and Gynecology, Debrecen, Hungary O75 B7 Costimulation and Intracellular Indoleamine-2,3-Dioxygenase Expression in Peripheral Blood of Healthy Pregnant and Preeclamptic Women Gergely Toldi, Attila Molvarec, László Berta, Anna Bajnok, János Rigó Jr Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary O76 The role of costimulatory molecules in the pathogenesis of pre-eclampsia Dorota Darmochwal-Kolarz¹, Bogdan Kolarz², Tomasz Chmielewski³, Jan Oleszczuk^{1 1}Medical University of Lublin, Department of Obstetrics and Perinatology, Lublin, Poland
²University of Rzeszow, Centre for Innovative Research in Medical and Natural Sciences, Rzeszow, Poland
³Medical University of Lublin, Depertment of Clinical Immunology, Lublin, Poland O77 Functional screening of Toll-like receptors in seven trophoblast cell lines Lobke Gierman¹, Guro Stødle¹, Line Tangerås¹, Marie Austdal², Guro Olsen¹, Turid Follestad³, Bente Skei¹, Kristin Rian⁴, Astrid Gundersen¹, Rigmor Austgulen¹, Ann-Charlotte Iversen^{1 1}Norwegian University of Science and Technology, Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine, Trondheim, Norway
²Norwegian University of Science and Technology, Department of Circulation and Medical Imaging, Trondheim, Norway
³Norwegian University of Science and Technology, Department of Mathematical Sciences, Trondheim, Norway
⁴Norwegian University of Science and Technology, Department of Laboratory Medicine, Children's and Women's Health, Trondheim, Norway O78 The inflammatory role of HMGB1 in preeclampsia Line Tangerås¹, Guro Stødle¹, Gabriela Silva¹, Liv Cecilie Thomsen², Lobke Gierman¹, Bente Skei¹, Karin Collett³, Merete Myklebost⁴, Anne Lise Beversmark⁴, Ragnhild Skråstad⁵, Rigmor Austgulen¹, Line Bjørge², Ann-Charlotte Iversen^{1 1}Norwegian University of Science and Technology, Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine, Trondheim, Norway
²Haukeland University Hospital, University of Bergen, Department of Obstetrics and Gynecology, Bergen, Norway
³Haukeland University Hospital, Department of Pathology, Bergen, Norway
⁴St. Olavs Hospital, Department of Obstetrics and Gynecology, Trondheim, Norway
⁵Norwegian University of Science and Technology and St. Olavs Hospital, Department of Obstetrics and Gynecology and Department of Laboratory Medicine Children's and Women's Health, Trondheim, Norway O137 Developing, disseminating, and implementing a core outcome set for pre-eclampsia James M. N. Duffy On behalf of iHOPE: International Collaboration to Harmonise Outcomes for Pre-eclampsia, University of Oxford, Oxford, United Kingdom

O79 An intermediate sFlt-1/PlGF ratio without preeclampsia indicates preterm delivery Victoria Ossada, Janine Hoffmann, Holger Stepan University of Leipzig, Department of Obstetrics, Leipzig, Germany O80 The SFLT-1/PlGF ratio associates with prolongation of pregnancy Langeza Saleh Erasmus MC, Department of Gynecology and Department of Obstetrics, Rotterdam, The Netherlands O81 The impact of uterine curettage post partum on maternal sFlt-1 concentration Victoria Ossada, Alexander Jank, Holger Stepan University of Leipzig, Department of Obstetrics, Leipzig, Germany O82 Association between anti-angiogenic factor and signs of arterial aging in women with preeclampsia Tansim Akhter¹, Anna-Karin Wikström¹, Marita Larsson¹, Anders Larsson², Tord Naessen^{1 1}Uppsala University, Obstetrics and Gynecology, Uppsala, Sweden
²Uppsala University, Clinical Chemistry, Uppsala, Sweden O83 Angiogenic factor imbalance contributes to the pathophysiology of preeclampsia among rural African women Allen Meeme Walter Sisulu University, Obstetrics and Gynecology, Mthatha, South Africa O84 Hydrogen sulphide rescues the preeclampsia phenotype aggravated by high sFlt-1 in placenta growth factor deficient pregnant mouse Shakil Ahmad, Keqing Wang, Asif Ahmed Aston University, Birmingham, Medical School, Birmingham, UK

WH85 Biomarker Discovery in Preeclampsia: present and future challenges: Taking a biomarker into clinical practice Lucy Chappell King's College London, Women's Health Academic Centre, London, UK WH86 Using proteomics for the discovery of biomarkers: promise and pitfalls Jenny Myers University of Manchester, Maternal & Fetal Health Research Centre, Manchester, UK

P33 Decreasing of placental progesterone induced blocking factor expression and spiral artery remodeling disturbance in mice preeclampsia model Manggala Pasca Wardhana¹, Budi Wicaksono¹, Erry Gumilar Dachlan¹, Muhammad Ilham Aldika Akbar¹, Ernawati Ernawati¹, Agus Sulistyono¹, Aditiawarman Aditiawarman¹, Hermanto Tri Juwono¹, Widjiati Widjiati^{2 1}Airlangga University, Department of Obstetrics and Gynecology, Surabaya, Indonesia
²Airlangga University, Medical Veterinary Faculty, Surabaya, Indonesia P87 Alteration of Delta-like ligand 1 and Notch 1 receptor in various placental disorders with special reference to early-onset preeclampsia Yota Shimanuki¹, Hiroyuki Mitomi², Yuki Fukumura³, Shintaro Makino¹, Atsuo Itakura¹, Takashi Yao³, Satoru Takeda^{1 1}Juntendo University Faculty of Medicine, Department of Obstetrics and Gynecology, Tokyo, Japan
²Dokkyo Medical University School of Medicine, Department of Surgical and Molecular Pathology, Tochigi, Japan
³Juntendo University Faculty of Medicine, Department of Human Pathology, Tokyo, Japan P88 Pre-eclampsia risk stratification for low risk 1st pregnancies: First results of a new LC-MS based multiplex metabolite assay Liz Bond¹, Grégoire Thomas², Caroline Nolan¹, Louise Kenny³, Philip Baker⁴, Robin Tuytten^{1 1}Metabolomic Diagnostics, Research and Development, Little Island, Ireland
²Squ4Re, Lokeren, Belgium
³Cork University Maternity Hospital, The Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland
⁴University of Auckland, Gravida: National Centre for Growth and Development, Auckland, New Zealand P89 Biochemical parameters of the first trimester in preeclampsia Mirjana Bogavac¹, Ana Jakovljevic², Aleksandra Nikolic³, Mirjana Milosevic-Tosic³, Zagorka Lozanov-Crvenkovic⁴, Zoran Novakovic^{5 1}University of Novi Sad Medical Faculty, Clinical Centre Vojvodina Department of Obstetrics and Gynecology , Novi Sad, Serbia
²University of Novi Sad Medical Faculty, Clinical Centre of Vojvodina, Centre for Laboratory Medicine, Novi Sad, Serbia
³University of Novi Sad Medical Faculty, Clinical Centre of Vojvodina, Emergency Center, Urgent Laboratory at Department of Obstetrics and Gynecology, Novi Sad, Serbia
⁴University of Novi Sad,Faculty of Science, Department of Mathematics and Informatics, Novi Sad, Serbia
⁵University of Novi Sad, Medical Faculty, Novi Sad, Serbia P90 Effect of angiotensin II receptor subtype2 stimulant on the pathogenesis of preeclampsia Keiichi Matsubara, Miki Mori, Yuka Uchikura, Yuko Matsubara Ehime University, Obstetrics and Gynecology, Toon, Japan P91 Possible Therapeutics for Preeclampsia: Drug Repositioning by In Vitro Screening via Induction of Placental Growth Factor Kazuya Mimura Osaka University Graduate School of Medicine, Department of Obstetrics and Gynecology, Suita, Japan P92 When there is a lack of magnesium during pregnancy Anna Vachulova¹, Monika Kaldararova², Andrea Vaskova³, Peter Tittel^{2 1}National Cardiovascular Insitute, Department of Arrhythmias and Permanent Pacing, Bratislava, Slovakia
²National Cardiovascular Insitute, Department of Functional Diagnostics, Bratislava, Slovakia
³J. A. Reiman University Hospital, Department of Gynecology and Obstetrics, Presov, Slovakia P93 Early-onset eclampsia with intrauterine fetal death after placental abruption at 22 weeks gestation: a case report and literature review Aiko Shigemitsu Nara Medical University, Department of Obstetrics & Gynecology, Kashihara, Japan P94 Preeclampsia in pregnancies with and without diabetes; the associations with placental weight. A population study of 655 842 pregnancies Johanne Dypvik¹, Ellen Marie Strøm-Roum¹, Camilla Haavaldsen¹, Lars Johan Vatten², Anne Eskild^{1 1}Akershus University Hospital, Department of Obstetrics & Gynecology, Lørenskog, Norway
²Norwegian University of Science and Technology (NTNU), Department of Public Health, Trondheim, Norway P95 Perinatal outcome of pregnant with severe preeclampsia and gestational diabetes mellitus in rondônia - brazil: case report Gizeli Gimenez¹, Ticiana Albuquerque Gonçalves¹, Maiky Jose de Oliveira², Rita Ferreira Silva^{1 1}Fundação Universidade Federal De Rondônia, Departamento De Medicina, Porto Velho, Brazil
²FACIMED, Cacoal, Porto Velho, Brazil P96 Neonatal outcome in women after kidney transplantation: effect of immunosuppressive therapy on the risk of preeclampsia Hester Zweers¹, Henk Van Hamersvelt², Renate Van der Molen³, Olivier Van der Heijden^{1 1}Radboud University Medical Centre Nijmegen, Department of Obstetrics and Perinatology, Nijmegen, The Netherlands
²Radboud University Medical Centre Nijmegen, Department of Renal Medicine, Nijmegen, The Netherlands
³Radboud University Medical Centre Nijmegen, Department of Medical Immunology, Nijmegen, The Netherlands P97 Chronic Kidney Disease and Pregnancy – A case report Sara Nascimento, Mariana Miranda, Teresa Matos, Fernanda Matos, Antónia Nazaré Hospital Prof. Doutor Fernando Fonseca, EPE, Department of Obstetrics and Gynecology, Amadora, Portugal P98 M Maternal lipid- and steroid hormone concentrations during the course of pregnancy and in pregnancy pathologies Ulrich Pecks¹, Nicola Kleine-Eggebrecht ², Nicolai Maass¹, Geneviève Escher³, Werner Rath², Markus Mohaupt^{3 1}University Hospital of Schleswig-Holstein Campus Kiel, 1st Department of Obstetrics and Gynaecology, Kiel, Germany
²University Hospital of the RWTH, 1st Department of Obstetrics and Gynaecology, Aachen, Germany
³University of Bern, Department of Nephrology, Hypertension and Clinical Pharmacology, Berne, Switzerland P99 Use of High Dose Cortisosteroids in HELLP Syndrome Ioana-Claudia Lakovschek, Christiane Barthel, Bence Csapo, Vassiliki Kolovetsiou-Kreiner, Christina Stern, Karoline Mayer-Pickel, Uwe Lang, Mila Cervar-Zivkovic Medical University of Graz, Department of Obstetrics & Gynecology, Graz, Austria P100 Differences in depression scores between women with a history of term hypertensive pregnancy disorders and women with a history of uncomplicated pregnancies. Wietske Hermes¹, Floortje Van Kesteren², Marielle Van Pampus³, Kitty Bloemenkamp⁴, Arie Franx⁵, Ben Mol⁶, Christianne De Groot^{7 1}Medical Center Haaglanden, Department of Obstetrics and Gynecology, The Hague, The Netherlands
²Academisch Medisch Centrum, Amsterdam, Department of Radiology, Amsterdam, The Netherlands
³Onze Lieve Vrouwe Gasthuis, Department of Obstetrics and Gynecology, Amsterdam, The Netherlands
⁴Leiden University Medical Center, Department of Obstetrics, Leiden, The Netherlands
⁵University Medical Center Utrecht, Department of Obstetrics and Gynecology, Utrecht, The Netherlands
⁶University of Adelaide, Department of Obstetrics and Gynecology, Adelaide, Australia
⁷VU Medical Center Amsterdam, Department of Obstetrics and Gynecology, Amsterdam, The Netherlands P101 Cardiac function and ventriculo-arterial interaction11 years after preeclampsia complicated pregnancy Maha Al-Nashi Karolinska University Hospital, Dept. Obstetrics, Stockholm, Sweden P102 Placental weight in the first pregnancy and risk for preeclampsia in second pregnancy: a population cohort study of 186 859 women Sandra Larsen¹, Johanne Dypvik¹, Camillla Haavaldsen¹, Lars Vatten², Anne Eskild^{1 1}Akershus University Hospital, Department of Obstetrics and Gynecology, Lørenskog, Norway
²Norwegian University of Science and Technology (NTNU), Department of Public Health, Trondheim, Norway P103 Relationship between severe preeclampsia onset with iugr incidence at dr. Soetomo General Hospital in 2013 Budi Wicaksono¹, Ryan Intan², Budi Utomo^{3 1}Soetomo General Hospital Surabaya Indonesia, Obstetric and Ginecology, Surabaya, Indonesia
²Airlangga University, Medical School, Surabaya, Indonesia
³Airlangga University, Public Health, Surabaya, Indonesia P104 Stromal derived factor-1α is a key to improving neonatal brain injuries Miki Mori¹, Keiichi Matsubara², Yuko Matsubara², Yuka Uchikura², Hiroshi Ochi^{1 1}Ehime Prefectural Central Hospital, Obstetrics and Gynecology, Matsuyama, Japan
²Ehime University, Obstetrics and Gynecology, Toon, Japan

STA105 PlGF: more than a pre-eclampsia biomarker. Results from the CoLAB Angiogenic Factor Study of 16 000 pregnancies Anne Cathrine Staff University of Oslo, Obstetrics and Gynecology, Oslo, Norway STA106 Maternal cardiac function before and during preeclampsia: we must study the heart in pregnacy Herbert Valensise University of Tor Vergata, Biomedical Imaging, Rome, Italy PL107 Monocytes in pregnancy and preeclampsia Marijke Faas University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands PL108 Inflammatory mechanisms in preeclampsia Attila Molvarec, János Rigó Jr. Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary PL109 Corticosteroids in the management of severe preeclampsia: what evidence? Alex Vidaeff Baylor College of Medicine, Obstetrics and Gynecology, Houston, USA

O110 Maternal Left Ventricular dysfunction and Remodeling in Pregnancy Complicated with Gestational Hypertension Orsolya Szenczi, János Rigó Jr. Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary O111 The association between maternal haemodynamics and pre-eclampsia: systematic review and meta-analysis Silvia Selvi¹, Basky Thilaganathan², Francesco D'Antonio², Lamberto Manzoli³, Asma Khalil^{2 1}St George's Hospital, University of London, Fetal Maternal Medicine Unit, London, UK
²St George's Hospital, University of London, Maternal-Fetal Department, London, UK
³University of Chieti-Pescara, Obstetrics and Gynecology, Rome, Italy O112 Inotropy index and ratio of potential to kinetic energy: Two novel parameters derived from continuous-wave Doppler ultrasound Sophie Bowe, Basky Thilaganathan, Elena Mantovani, Asma Khalil St George's Hospital, University of London, Maternal-Fetal Department, London, UK O113 Measurements of arterial stiffness and uterine artery Doppler for the prediction of preeclampsia in women presenting with gestational hypertension Asma Khalil, Sophie Bowe, Basky Thilaganathan, Dimuthu Vinayagam, Elena Mantovani St George's Hospital, University of London, Maternal-Fetal Department, London, UK O114 Maternal cardiovascular changes in pregnancies complicated by small for gestational age neonate with or without maternal hypertension Sophie Bowe, Basky Thilaganathan, Dimuthu Vinayagam, Asma Khalil St George's Hospital, University of London, Maternal-Fetal Department, London, UK O115 First trimester maternal vascular function is associated with fetal growth Charlotte Iacobaeus¹, Thomas Kahan¹, Ellika Andolf¹, Malin Thorsell¹, Gun Jörneskog¹, Katarna Bremme^{2 1}Karolinska Institute, Department of Clinical Science, Danderyd Hospital, Stockholm, Sweden
²Karolinska Institute, Department of Women’s and Children’s Health, Stockholm, Sweden O116 Can maternal haemodynamics predict hypertensive disorders in pregnancy? Asma Khalil St George's Hospital, University of London, Maternal-Fetal Department, London, UK

O117 Role of some biomarkers in long term cardiovascular prognosis of pregnancy hypertensive disease Manuel Bicho¹, Andreia Matos¹, Alda Pereira da Silva¹, Maria Clara Bicho¹, Maria José Areias², Irene Rebelo^{3 1}University of Lisbon, Faculty of Medicine, Genetics Laboratory and Environmental Health Institute, Lisbon, Portugal
²Maria Pia Hospital, Júlio Diniz Maternity, Porto, Portugal
³Faculty of Pharmacy/ Institute for Molecular and Cell Biology, University of Porto, Laboratory of Biochemistry, Porto, Portugal O118 Subsequent preeclampsia is associated with worse subclinical left ventricular dysfunction York Yann Chow¹, Deven Mahadavan², Gus Dekker³, Noriko Warren², Melanie Wittwer¹, Vikki Clifton⁴, Margaret Arstall^{1 1}Lyell McEwin Hospital, University of Adelaide, Department of Cardiology, Adelaide, Australia
²Lyell McEwin Hosptial , Department of Cardiology, Adelaide, Australia
³Lyell McEwin Hospital, University of Adelaide, Department of Gynecology and Department of Obstetrics, Adelaide, Australia
⁴Mater Medial Research Institute, Wollongabba, Australia O119 Cardiovascular risk management after reproductive and pregnancy related disorders: a Dutch multidisciplinary evidence-based guideline Karst Heida¹, Michiel Bots², Miram Cohen³, Frederique Van Dunné⁴, Christianne De Groot⁵, Nurah Hammoud¹, Annemiek Hoek⁶, Joop Laven⁷, Angela Maas⁸, Jeanine Roeters van Lennep⁹, Birgitta Velthuis¹⁰, Arie Franx^{1 1}University Medical Center Utrecht, Department of Obstetrics, Utrecht, The Netherlands
²University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
³Camper Practice, Primary Care, Amsterdam, The Netherlands
⁴Medical Center Haaglanden, Department of Obstetrics, The Hague, The Netherlands
⁵VU Medical Center Amsterdam, Department of Obstetrics, Amsterdam, The Netherlands
⁶University Medical Center Groningen, Department of Obstetrics & Gynecology, Groningen, The Netherlands
⁷Erasmus MC, Department of Obstetrics & Gynecology, Rotterdam, The Netherlands
⁸Radboud University Medical Center, Department of Cardiology, Nijmegen, The Netherlands
⁹Erasmus MC, Department of Internal Medicine, Rotterdam, The Netherlands
¹⁰University Medical Center Utrecht, Department of Radiology, Utrecht, The Netherlands O120 Increased myeloperoxidase is a cardiovascular risk biomarker in women with previous preeclampsia Andreia Matos¹, Alice Rivera², Alda Pereira da Silva¹, Ana Portelinha³, Maria José Areias⁴, Irene Rebelo⁵, Manuel Bicho¹, José R. Romero^{6 1}Faculty of Medicine of University of Lisbon and Instituto de Investigação Científica Bento da Rocha Cabral, Genetics Laboratory and Environmental Health Institute, Lisbon, Portugal
²Boston Children’s Hospital and Harvard Medical School, Depts. of Pathology and Laboratory Medicine, Boston, USA
³New University of Lisbon, Chronic Diseases Research Centre (CEDOC), Lisbon, Portugal
⁴Maria Pia Hospital, Júlio Diniz Maternity, Porto, Portugal
⁵Faculty of Pharmacy/ Institute for Molecular and Cell Biology, University of Porto, Laboratory of Biochemistry, Porto, Portugal
⁶Brigham and Women’s Hospital and Dept. of Medicine, Harvard Medical School, Div. of Endocrinology, Diabetes and Hypertension, Boston, USA O121 Maternal metabolic outcomes in women with a history of hypertensive pregnancy disorders Laura Benschop¹, Jeanine E. Roeters-van Lennep², Sarah Schalekamp-Timmermans¹, Vincent W.V. Jaddoe³, Nienke E. Bergen¹, Eric A.P. Steegers^{1 1}Erasmus MC, Department of Obstetrics & Gynecology, Rotterdam, The Netherlands
²Erasmus MC, Department of Internal Medicine, Rotterdam, The Netherlands
³Erasmus MC, Dept. Epideimology & Dept. Pediatrics, Rotterdam, The Netherlands O122 The role of framing in modifying behavior to reduce cardiovascular risk after preeclampsia, a vignette study Anouk Bokslag¹, Wietske Hermes², Christianne De Groot¹, Pim Teunissen^{3 1}VU Medical Center Amsterdam, Department of Obstetrics & Gynecology, Amsterdam, The Netherlands
²Medical Center Haaglanden, Department of Obstetrics & Gynecology, The Hague, The Netherlands
³VU Medical Center Amsterdam, 1st Department of Obstetrics and Gynaecology, Amsterdam, The Netherlands O123 Hypertensive disorders of pregnancy and subsequent risk of cancer – a population-based cohort study Ida Behrens¹, Saima Basit², Allan Jensen³, Jacob Lykke⁴, Lars Peter Nielsen⁵, Jan Wohlfahrt², Susanne Krüger Kjaer³, Mads Melbye², Heather Boyd^{2 1}Statens Serum Institut, Dept. of Epidemiology Research, Copenhagen, Denmark
²Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark
³The Danish Cancer Society Research Center, Unit of Virus, Lifestyle and Genes, Copenhagen, Denmark
⁴Copenhagen University Hospital, Hvidovre, Department of Obstetrics and Gynecology, Copenhagen, Denmark
⁵Statens Serum Institut, Department of Autoimmunology and Biomarkers, Copenhagen, Denmark

O124 Preeclampsia: Two different clinical phenotypes - two different pregnancy outcomes Zulfiya Khodzhaeva Moscow Federal Research Center for Ob-Gyn & Perinatology, Maternal-Fetal Department, Moscow, Russia O125 Ethnicity: an independent risk factor for adverse perinatal outcome in women with chronic hypertension Louise Webster1, Kate Bramham1, Paul Seed1, Michelle Homsy1, Catherine Nelson-Piercy1, Basky Thilaganathan2, Lucy Chappell1 ¹King's College London, Women's Health Academic Centre, London, UK
²St George's Hospital, University of London, Fetal Maternal Medicine Unit, London, UK O126 Postnatal neurological development follow-up of newborns from pregnancies with hypertension associated intrauterine growth restriction (IUGR) József Gábor Joó, Boróka Ujvárosi, Anna Beke, János Rigó Jr. Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary O127 Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome Yasuhiko Ebina1, Masahiro Ieko2, Sumiyoshi Naito3, Gen Kobashi4, Masashi Deguchi1, Hisanori Minakami5, Tatsuya Atsumi6, Hideto Yamada1 ¹Kobe University Graduate School of Medicine, Department of Obstetrics and Gynecology, Kobe, Japan
²Health Sciences University of Hokkaido, Department of Internal Medicine, Ishikari-Tobetsu, Japan
³Health Sciences University of Hokkaido, Department of Clinical Laboratory, Ishikari-Tobetsu, Japan
⁴Dokkyo Medical University School of Medicine, Department of Public Hearth, Mibu, Japan
⁵Hokkaido University Graduate School of Medicine, Department of Obstetrics and Gynecology, Sapporo, Japan
⁶Hokkaido University Graduate School of Medicine, Department of Medicine II, Sapporo, Japan O128 Placental vascularization indices and uterine artery peak systolic velocity in pregnancy hypertension Ábel Tamás Altorjay¹, Andrea Surányi¹, Tibor Nyári², Gábor Németh^{1 1}University of Szeged, Department of Obstetrics and Gynecology, Szeged, Hungary ²University of Szeged, Department of Medical Physics and Informatics, Szeged, Hungary

O130 Urinary congophilia in women with preeclampsia and chronic kidney disease Fergus McCarthy¹, Adedamola Adetoba², Carolyn Gill², Kate Braham², Maria Bertolaccini², Guillermina Girardi², Lucilla Poston², Lucy Chappell^{2 1}King's College London, Women's Health Academic Centre, London, UK
²King's College London, Division of Women's Health, London, UK O131 Pravastatin protects against glucose-induced anti-proliferative, anti-invasive and anti-angiogenic milieu in cytotrophoblasts M. Nasir Uddin Texas A&M Health Care Centre, Department of Obstetrics & Gynecology, Temple, USA O132 Comparison of groups with and without diabetes mellitus and preeclampsia in pregnancy: a retrospective case-control comparison M. Nasir Uddin Texas A&M Health Care Centre, Department of Obstetrics & Gynecology, Temple, USA O133 Fetal renal vascularisation in pregnancy induced hypertension complicated by gestational diabetes or intrauterine growth restriction Andrea Surányi, Ábel Altorjay, Gábor Németh University of Szeged, Department of Obstetrics & Gynecology, Szeged, Hungary O134 Polycystic ovary syndrome as a risk factor of pregnancy induced hypertension - review of the literature Szabolcs Varbiro Semmelweis University, Department of Obstetrics & Gynecology, Budapest, Hungary O135 HELLP??? - a case Eva-Christine Weiss, Gordana Tomasch, Uwe Lang, Wolfgang Schöll Medical University of Graz, Department of Obstetrics & Gynecology, Graz, Austria